#5 has been found to be safer than Botox and effective in reducing wrinkles, with efficacies up to 48% upon 4 weeks of twice daily treatment. However, the skin permeation of Arg0 is poor, due to its large molecular weight and hydrophilicity.
¿De donde sacas el 100 millones de veces? El artículo le pone bastantes pegas la verdad. Deja los clickbaits para la prensa sensacionalista.
#1 Aquí el artículo https://www.nature.com/articles/s41598-017-18454-z