Según los científicos, el aumento en las tasas de condiciones tales como la esquizofrenia o el autismo puede ser un debidas de la creciente edad de la paternidad
#1#2 joder, sois la ostia de listos, porque los científicos de Islandia, UK y Dinamarca que publicaron esto:" but their data also reveal that, although a 20-year-old father transmits, on average, approximately 25 mutations to his child, a 40-year-old father transmits around 65. This means that every additional year of paternal age results in an average of two extra mutations in human offspring. By contrast, the authors found that the number of de novo mutations transmitted by the mother is always roughly 15, regardless of her age." en Nature, no tenían ni idea hasta que realizaron su estudio de ultrasecuenciación en 78 trios islandeses...
A ver, lo único que estoy diciendo es que la hipótesis de trabajo sobre la que han hecho los experimentos es lógica.
Los experimentos confirman la lógica.
De tu propio artículo: In the 1930s, the pioneering geneticist J. B. S. Haldane noticed a peculiar inheritance pattern in families with long histories of haemophilia. The faulty mutation responsible for the blood-clotting disorder tended to arise on the X chromosomes that fathers passed to their daughters, rather than on those that mothers passed down. Haldane subsequently proposed1 that children inherit more mutations from their fathers than their mothers, although he acknowledged that “it is difficult to see how this could be proved or disproved for many years to come”.
Comentarios
#4 Mira aquí, hasta le dedican la portada. Puedes leer el "about the cover"
http://www.nature.com/nature/current_issue.html
Aquí una editorial
http://www.nature.com/news/fathers-bequeath-more-mutations-as-they-age-1.11247
Aquí la noticia
http://www.nature.com/nature/journal/v488/n7412/full/488467a.html
y aquí el artículo original (si no tienes acceso te mando el pdf con mucho gusto)
http://www.nature.com/nature/journal/v488/n7412/full/nature11396.html
¿Cómo puede ser esto?
¿Células más viejas que fallan? Nunca lo hubiese creído posible.
#1 #2 joder, sois la ostia de listos, porque los científicos de Islandia, UK y Dinamarca que publicaron esto:" but their data also reveal that, although a 20-year-old father transmits, on average, approximately 25 mutations to his child, a 40-year-old father transmits around 65. This means that every additional year of paternal age results in an average of two extra mutations in human offspring. By contrast, the authors found that the number of de novo mutations transmitted by the mother is always roughly 15, regardless of her age." en Nature, no tenían ni idea hasta que realizaron su estudio de ultrasecuenciación en 78 trios islandeses...
#3 No. En Nature no tenían pruebas concluyentes, que es otra cosa muy distinta.
Alguna idea sí que tendrían cuando planearon los experimentos buscando un resultado...
Claaaarooo... por eso mi hermano pequeño, 11 años menor, es mas alto, mas delgado y con mas pelo que yo... claaaaro!
¿Y?
A ver, lo único que estoy diciendo es que la hipótesis de trabajo sobre la que han hecho los experimentos es lógica.
Los experimentos confirman la lógica.
De tu propio artículo:
In the 1930s, the pioneering geneticist J. B. S. Haldane noticed a peculiar inheritance pattern in families with long histories of haemophilia. The faulty mutation responsible for the blood-clotting disorder tended to arise on the X chromosomes that fathers passed to their daughters, rather than on those that mothers passed down. Haldane subsequently proposed1 that children inherit more mutations from their fathers than their mothers, although he acknowledged that “it is difficult to see how this could be proved or disproved for many years to come”.