#12 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

kaos_subversivo — Fri, 16 Aug 2024 06:41:12 +0000

#5 no, ni siquiera he votado, solo he preguntado si eso se considera muro de pago

» autor: kaos_subversivo

#11 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

LondoMolari — Thu, 15 Aug 2024 22:11:02 +0000

@MikeR tiene razón, @NPC1 el artículo en si es interesante pero ni de coña pone lo que tú escribes en el titular..

Pero sigue siendo interesante, como he dicho.

» autor: LondoMolari

#10 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

MikeR — Thu, 15 Aug 2024 20:22:19 +0000

#9 ni de lejos. El título sigue igual, pero tu a lo tuyo

» autor: MikeR

#9 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

NPCristo — Thu, 15 Aug 2024 20:18:56 +0000

#8 #6 arreglao

» autor: NPCristo

#8 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

MikeR — Thu, 15 Aug 2024 20:13:12 +0000

#7 acabo de modificar el comentario, ya que tanto te interesa

» autor: MikeR

#7 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

NPCristo — Thu, 15 Aug 2024 20:12:18 +0000

#6 Cuéntame

» autor: NPCristo

#6 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

MikeR — Thu, 15 Aug 2024 20:09:43 +0000

De lo que has puesto de título a lo que dice realmente el artículo...

"Thyroid hormone suppresses medulloblastoma progression through promoting terminal differentiation of tumor cells" Título original.
O sea, la hormona tifoidea frena/revierte 1 tipo de cáncer.

Lo siento, pero microblogging, has cambiado por completo el sentido

» autor: MikeR

#5 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

NPCristo — Thu, 15 Aug 2024 20:09:32 +0000

#4 Entonces quieres que cancele una noticia que es buena para la humanidad porque solo puedes ver una parte?

» autor: NPCristo

#4 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

kaos_subversivo — Thu, 15 Aug 2024 20:07:18 +0000

#2 #3 solo estais viendo el resumen, no el articulo completo.
Lo que has copiado:

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Mi pantallazo, vaya

» autor: kaos_subversivo

#3 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

helia — Thu, 15 Aug 2024 20:05:07 +0000

#2 Yo uso Chrome y lo he podido leer.

» autor: helia

#2 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

NPCristo — Thu, 15 Aug 2024 20:01:20 +0000

#1 Con Chrome sí salta pero no uso chrome

Igualmente te copio y pego

•
T3 induces terminal differentiation of MB tumor cells through upregulating NeuroD1
•
T3 promotes NeuroD1 transcription by interfering with TRα1 and EZH2 interaction
•
T3 represses the growth of human and mouse tumors from multiple MB groups
•
T3-induced differentiation is an effective and safe strategy for MB treatment
Summary
Hypothyroidism is commonly detected in patients with medulloblastoma (MB). However, whether thyroid hormone (TH) contributes to MB pathogenicity remains undetermined. Here, we find that TH plays a critical role in promoting tumor cell differentiation. Reduction in TH levels frees the TH receptor, TRα1, to bind to EZH2 and repress expression of NeuroD1, a transcription factor that drives tumor cell differentiation. Increased TH reverses EZH2-mediated repression of NeuroD1 by abrogating the binding of EZH2 and TRα1, thereby stimulating tumor cell differentiation and reducing MB growth. Importantly, TH-induced differentiation of tumor cells is not restricted by the molecular subgroup of MB, suggesting that TH can be used to broadly treat MB subgroups. These findings establish an unprecedented association between TH signaling and MB pathogenicity, providing solid evidence for TH as a promising modality for MB treatment.
Graphical abstract
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Keywords
medulloblastoma
differentiation therapy
terminal differentiation
thyroid hormone
hypothyroidism
epigenetic regulation
EZH2
NeuroD1
TRα1
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» autor: NPCristo

#1 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

kaos_subversivo — Thu, 15 Aug 2024 19:56:58 +0000

Muro de pago?

» autor: kaos_subversivo

ciencia: comentarios [3969485]

#12 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

#11 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

#10 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

#9 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

#8 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

#7 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

#6 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

#5 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

#4 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

#3 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

#2 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad

#1 La hormona tiroidea hace que las células cancerosas vuelvan a la normalidad